Publications

The following selection of publications demonstrates PHENOS scientific background:

1:

Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, Shushakova N.

Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.
Nephrol Dial Transplant. 2018 Sep 21.[Epub ahead of print]
PMID: 30247663

2:

Wang L, Balzer MS, Rong S, Menne J, von Vietinghoff S, Dong L, Gueler F, Jang MS, Xu G, Timrott K, Tkachuk S, Hiss M, Haller H, Shushakova N.

Protein kinase C a inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate.
Kidney Int. 2016 Jun;89(6):1253-67.
PMID: 27142955

3:

Gueler F, Shushakova N, Mengel M, Hueper K, Chen R, Liu X, Park JK, Haller H, Wensvoort G, Rong S.

A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice.
PLoSOne. 2015 Jan 24;10(1):e0115709.
PMID: 25617900

4:

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F.

Renal PKC-e deficiency attenuates acute kidney injury and ischemic allograft injury via TNF-a-dependent inhibition of apoptosis and inflammation.
Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F718-26.
PMID: 25056349

5:

Menne J, Shushakova N, Bartels J, Kiyan Y, Laudeley R, Haller H, Park JK, Meier M.

Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy. Diabetes.2013 Apr;62(4):1167-74.
PMID: 23434935

6:

Lu X, Li N, Shushakova N, Schmitt R, Menne J, Susnik N, Meier M, Leitges M, Haller H, Gueler F, Rong S.

C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.
J Nephrol. 2012 Sep-Oct;25(5):738-43.
PMID: 22180224

7:

Blume C, Felix A, Shushakova N, Gueler F, Falk CS, Haller H, Schrader J.

Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury. PLoS One. 2012;7(5):e37100.
PMID: 22666342

8:

Bertram A, Zhang H, von Vietinghoff S, de Pablo C, Haller H, Shushakova N, Ley K.

Protein kinase C-Θ is required for murine neutrophil recruitment and adhesion strengthening under flow. J Immunol. 2012 Apr 15;188(8):4043-51.
PMID: 22403440

9:

Gueler F, Rong S, Gwinner W, Mengel M, Bröcker V, Schön S, Greten TF, Hawlisch H, Polakowski T, Schnatbaum K, Menne J, Haller H, Shushakova N.

Complement 5a receptor inhibition improves renal allograft survival.
J Am Soc Nephrol. 2008 Dec;19(12):2302-12.
PMID: 18753257

10:

Gueler F, Park JK, Rong S, Kirsch T, Lindschau C, Zheng W, Elger M, Fiebeler A, Fliser D, Luft FC, Haller H.

Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages.
Am J Pathol. 2007 Apr;170(4):1192-9.
PMID: 17392159

11:

Meier M, Menne J, Park JK, Holtz M, Gueler F, Kirsch T, Schiffer M, Mengel M, Lindschau C, Leitges M, Haller H.

Deletion of Protein Kinase C-{varepsilon} Signaling Pathway Induces Glomerulosclerosis and Tubulointerstitial Fibrosis In Vivo.
J Am Soc Nephrol. 2007 Apr;18(4):1190-8. Epub 2007 Mar 14.
PMID: 17360953

12:

Meier M, Park JK, Overheu D, Kirsch T, Lindschau C, Gueler F, Leitges M, Menne J, Haller H.

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.
Diabetes. 2007 Feb;56(2):346-54.
PMID: 17259378

13:

Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, Ociepka R, Leitges M, Rinta-Valkama J, Holthofer H, Haller H.

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.
Kidney Int. 2006 Oct;70(8):1456-62. Epub 2006 Sep 6.
PMID: 16955103

14:

Ziegler E, Gueler F, Rong S, Mengel M, Witzke O, Kribben A, Haller H, Kunzendorf U, Krautwald S.

CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking.
J Am Soc Nephrol. 2006 Sep;17(9):2521-32. Epub 2006 Aug 9.
PMID: 16899521

15:

Menne J, Park JK, Agrawal R, Lindschau C, Kielstein JT, Kirsch T, Marx A, Muller D, Bahlmann FH, Meier M, Bode-Boger SM, Haller H, Fliser D.

Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers.
FASEB J. 2006 May;20(7):994-6. Epub 2006 Apr 5.
PMID: 16597674

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